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  • Spatiotemporal atlas of the fetal brain depicts cortical developmental gradient | Journal of Neuroscience
    The fetal brains experience rapid and complex development in utero during the second and third trimesters. In utero MRI of the fetal brain in this period enables us to quantify normal fetal brain development in the spatiotemporal domain. In this study, we established a high-quality spatiotemporal atlas between 23-38 gestational weeks (GA) from 90 healthy Chinese human fetuses of both sexes using a pairwise and groupwise registration pipeline. We quantified the fetal cortical morphology indices and characterized their spatiotemporal developmental pattern. The cortical thickness exhibited a biphasic pattern that first increased and then decreased; the curvature fitted well into the Gompertz growth model; sulcal depth increased linearly while surface area expanded exponentially. The cortical thickness and curvature trajectories consistently pointed to a characteristic time-point around GA of 31 weeks. The characteristic GA and growth rate obtained from individual cortical regions suggested a central-to-periph...
    Nov 2, 2022 Xinyi Xu
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