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Common micro- and macroscale principles of connectivity in the human brain | Journal of NeuroscienceThe brain requires efficient information transfer between neurons and between large-scale brain regions. Brain connectivity follows predictable organizational principles: at the cellular level, larger supragranular pyramidal neurons have larger, more branched dendritic trees, more synapses, and perform more complex computations; at the macroscale, region-to-region connections display a diverse architecture with highly-connected hub-areas facilitating complex information integration and computation. Here, we explore the hypothesis that branching structure of large-scale region-to-region connectivity follows similar organizational principles as the neuronal scale. We examine microscale connectivity of basal dendritic trees of supragranular pyramidal neurons (300+) across ten cortical areas in five human donor brains (1M/4F). Dendritic complexity was quantified as number of branch points, tree length, spine count, spine density and overall branching complexity. High-resolution diffusion-weighted MRI was used ...Apr 14, 2022