Striatonigral Degeneration

Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.

Treatment

There is no cure for striatonigral degeneration, and treatments for the disorder have variable success. Treatments used for Parkinson's disease are recommended. However, unlike Parkinson's disease, striatonigral degeneration is not responsive to levodopa. Dopamine and anticholinergics provide some benefit. Generally, treatment is reevaluated as the disorder progresses.

Prognosis

Striatonigral degeneration progresses slowly. Some patients have normal life expectancy.

Research

The NINDS supports and conducts research on disorders of the brain and nervous system such as striatonigral degeneration. This research focuses on finding ways to prevent and treat these disorders.

Organizations

National Organization for Rare Disorders (NORD)
Federation of voluntary health organizations dedicated to helping people with rare "orphan" diseases and assisting the organizations that serve them. Committed to the identification, treatment, and cure of rare disorders through programs of education, advocacy, research, and service.

55 Kenosia Avenue
Danbury, CT 06810
orphan@rarediseases.org
http://www.rarediseases.org
Tel: Danbury
Fax: 203-798-2291

American Parkinson Disease Association
Seeks to “Ease the Burden – Find the Cure” through funding scientific research. Provides comprehensive patient/caregiver support and education.

135 Parkinson Avenue
Staten Island, NY 10305-1425
apda@apdaparkinson.org
http://www.apdaparkinson.org
Tel: Staten Island
Fax: 718-981-4399

National Parkinson Foundation
Provides research, patient services, clinical studies, public and professional education, and physician referrals at over 60 locations and through a nationwide network of chapters and support groups.

201 SE 1st Street
Suite 800
Miami, FL 33137
helpline@parkinson.org
http://www.parkinson.org
Tel: Miami
Fax: 305-243-5595

Parkinson's Action Network (PAN)
Non-profit education and advocacy organization that serves as a voice for the Parkinson's community by fighting for promising research that will produce effective treatments and a cure.

1025 Vermont Ave., NW
Suite 1120
Washington, DC 20005
info@parkinsonsaction.org
http://www.parkinsonsaction.org
Tel: Washington
Fax: 202-638-7257

Content Provided By

NINDS Disorders is an index of neurological conditions provided by the National Institute of Neurological Disorders and Stroke. This valuable tool offers detailed descriptions, facts on treatment and prognosis, and patient organization contact information for over 500 identified neurological disorders.

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