Image of the Week

Quadriceps Nerve

  • Published1 Jan 2012
  • Reviewed1 Jan 2012
  • Source BrainFacts/SfN
A cross section through a mouse quadriceps nerve showing discontinuous Drp2 staining (green) in the plasma membrane of Schwann cells, with axons stained for neurofilament (blue) and myelin stained for P0 (red). For more information, see the article by C. Stewart Gillespie, and Peter J. Brophy in The Journal of Neuroscience.
Sherman et al. The Journal of Neuroscience, 2012.

Glial cells help nerve cells communicate with one another by providing them with insulating layers of fats and protein called myelin, which allows the neuron’s electrical impulses to zip through axons without loss.

In the peripheral nervous system — where nerves in the body connect muscles and organs to the brain — these cells are called Schwann cells. When Schwann cells are altered, they often lose their ability to correctly perform their roles.

In a recent animal study in The Journal of Neuroscience, researchers at the University of Edinburgh examined the role of two specific proteins, periaxin and dystrophin-related protein 2 (Drp2), in Schwann cell growth, when myelination occurs.

Loss of one of these proteins is known to cause myelin damage in humans. In Charcot-Marie-Tooth disease, a relatively common hereditary condition, gene mutations and proteins compromise normal muscle functions, such as walking.

In this study, the scientists concluded not only are the proteins’ presence essential to proper Schwann cell growth, but so is their interaction.

The image above shows a cross-section view of a mouse quadriceps nerve showing Drp2 staining in green in the plasma membrane of Schwann cells. Myelin is stained in red, surrounding the blue axons.



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