The Wiring Behind Your Reflexes
- Published7 Aug 2018
- Reviewed7 Aug 2018
- Author Charlie Wood
- Source BrainFacts/SfN
Has a doctor ever tested your reflexes with a light whack of your knee? When that little red hammer taps your knee, your leg pops up almost as if it has a mind of its own. That's because — in a sense — it does. Your knee has access to its own bit of grey matter far from your head — your spinal cord.
The neurons that run from your skin to your spinal cord independently handle a range of reflexive reactions, protecting us from immediate threats like unseen thumbtacks to still-hot electric burners. To get the pain signal from your skin to your spine for on-the-spot processing, you need this orange blob of nerves — the dorsal root ganglion.
In this image, the nerve bundle stays strictly in its lane. In a normal petri dish it would sprawl in all directions, but here the green stripes corral it with a repulsive protein — EphrinA5. This protein family serves as a traffic light in the body that helps direct neurons as they grow.
CONTENT PROVIDED BY
Gavazzi, I. Chemorepulsion of DRG sensory neuron. Wellcome Collection. Retrieved August 7, 2018, from https://wellcomecollection.org/works/ghxufyf8.
Cho, H. et al. Mechanosensitive Ion Channels in Cultured Sensory Neurons of Neonatal Rats. Journal of Neuroscience 15 February 2002, 22 (4) 1238-1247. Retrieved August 7, 2018, from http://www.jneurosci.org/content/22/4/1238.long#sec-16
Knee-Jerk Reflex. Encyclopedia Britannica. Retrieved August 7, 2018 from https://www.britannica.com/science/knee-jerk-reflexMarquardt, T. et al. Coexpressed EphA Receptors and Ephrin-A Ligands Mediate Opposing Actions on Growth Cone Navigation from Distinct Membrane Domains.Cell 121, (1), 127-139, April 8 2005. Retrieved August 7, 2018 from https://www.cell.com/cell/fulltext/S0092-8674(05)00094-2