Brain Byte

Interstitial Cells of Cajal

  • Published13 Nov 2020
  • Author Calli McMurray
  • Source BrainFacts/SfN

The gut’s pacemaker cells, interstitial cells of Cajal, produce slow electrical waves to keep food moving through the digestive tract.

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 Interstitial Cells of Cajal Brain byte
Design by A. Tong

Design by Adrienne Tong.

Image "Physiology, Injury, and Recovery of Interstitial Cells of Cajal" by Huizinga et al. Gastroenterology, 2009.



Huizinga, J. D., Chen, J., Mikkelsen, H. B., Wang, X., Parsons, S. P., & Zhu, Y. F. (2013). Interstitial cells of Cajal, from structure to function. Frontiers in Neuroscience, 7. doi:10.3389/fnins.2013.00043 

Al-Shboul, O. A. (2013). The Importance of Interstitial Cells of Cajal in the Gastrointestinal Tract. Saudi J Gastroenterol, 19(1), 3-15. doi:10.4103/1319-3767.105909

Huizinga, J. D., Zarate, N., & Farrugia, G. (2009). Physiology, Injury, and Recovery of Interstitial Cells of Cajal: Basic and Clinical Science. Gastroenterology, 137(5), 1548-1556. doi:10.1053/j.gastro.2009.09.023

Klein, S., Seidler, B., Kettenberger, A., Sibaev, A., Rohn, M., Feil, R., . . . Saur, D. (2013). Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nature Communications, 4(1). doi:10.1038/ncomms2626

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