Deep Inside the Brain, Light-Sensing Cells Control Body Temperature

  • Published5 Jan 2021
  • Author Calli McMurray
  • Source BrainFacts/SfN
Evolution of Mammalian Opn5
Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation” by Takahiro Yamashita et al.
Yamashita et al., 2014

Light-detecting proteins called opsins sit in the back of the retina and kickstart your sense of vision. But one of these proteins, opsin 5, lives deep inside the brain and detects light without help from the eyes. Violet light, a wavelength abundant in natural light, can pass through the skull straight to opsin 5 neurons.

These neurons (dark purple) reside in the preoptic area (light purple) of mice, a brain region that regulates body temperature and other aspects of homeostasis. They also receive information from a skin temperature-sensing brain circuit and send information to brown adipose tissue. The “good” type of fat, brown adipose tissue, burns lipids and carbs to generate heat and raise body temperature. The tissue is unique to mammals, equipping them to endure the cold and survive on sparse diets. But heat generation is an energy-sucking process, so brown adipose tissue springs into action only when it’s needed.

When opsin 5 neurons detect violet light, they inhibit brown adipose tissue activity and keep the body temperature stable. In the absence of violet light, opsin 5 neurons allow brown adipose tissue to generate heat and raise the body temperature. Detecting changes in light lets mammals calibrate their body temperature to the environment. But for modern humans, artificial light lacking the violet wavelengths may leave opsin 5 neurons under-stimulated. This disrupts the body’s ability to break down fats and carbs, which can lead to metabolic dysfunction.



Cannon, B., & Nedergaard, J. (2004). Brown adipose tissue: function and physiological significance. Physiological reviews, 84(1), 277–359. doi: 10.1152/physrev.00015.2003. 

Schwartz, G. (2020, September 02). Light-activated neurons deep in the brain control body heat. Retrieved October 27, 2020, from https://www.nature.com/articles/d41586-020-02481-4

Yu, S., François, M., Huesing, C., & Münzberg, H. (2018). The Hypothalamic Preoptic Area and Body Weight Control. Neuroendocrinology, 106(2), 187–194. doi: 10.1159/000479875

Zhang, K. X., D’Souza, S., Upton, B. A., Kernodle, S., Vemaraju, S., Nayak, G., … Lang, R. A. (2020). Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Nature, 585(7825), 420–425. doi: 10.1038/s41586-020-2683-0

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