There are some things you wouldn't wish upon even your worst enemy. Stepping on Legos being no such exception. The mind bending pain of a bare foot pressing down on a Lego is one of the worst known to humanity, but how does something so innocent looking create such an intense feeling? We're talking nociception today folks, and the chemistry of how these little two gram blocks pack enough punch to send you into orbit in this video from Reactions.
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American Chemical Society